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PKR诱导细胞凋亡发生机制的研究进展 被引量：3

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摘要 凋亡是可以由多种细胞内外刺激因素引发的细胞程序性死亡[1]。凋亡可由生理性因素导致,如生长因子的缺失、细胞表面蛋白的抗体绑定[2],杀伤性T淋巴细胞的Fas配体[3]的分泌。此外,大量细胞毒性因子也可启动细胞的凋亡,如电离辐射和各种化疗药物(足叶乙甙,阿霉素等[4])。细胞凋亡相关因子的失调(包括过度的激活或者抑制)
作者 段玉坤 伍志强 韩为东 孟元光
机构地区 解放军总医院妇产科 解放军总医院基础医学研究所
出处 《现代肿瘤医学》 CAS 2011年第9期1863-1865,共3页 Journal of Modern Oncology
基金 国家自然科学基金项目(编号:81071617 81001184)
关键词 PKR 细胞凋亡 肿瘤
分类号 R730 [医药卫生—肿瘤]
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参考文献28

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  • 4Dharel N,Kato N,Muroyama R,et al.Potential contribution oftumor suppressor p53 in the host defense against hepatitis C virus. Molecular Biology of the Cell . 2010
  • 5Philippos Peidis,Andreas I Papadakis,Kamindla Rajesh,et al.HDAC pharmacological inhibition promotes cell death through theeIF2αkinases PKR and GCN2. Cancer . 2010
  • 6Guo Zhang,Margaret A Park,Clint Mitchell,et al.Multiple cyclinkinase inhibitors promote bile acid-induced apoptosis and auto-phagy in primary hepatocytes via p53-CD95-dependent signa-ling. Journal of Biological Chemistry . 2008
  • 7Willis KL,Langland JO,Shisler JL.Phosphorylation of the NFARproteins by the dsRNA-dependent protein kinase PKR consti-tutes a novel mechanism of translational regulation and cellular de-fense. Genes and Development . 2010
  • 8Xuerui Yang Christina Chan.Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2[J].Cell Research,2009,19(4):469-486. 被引量：5
  • 9Von Roretz C,Gallouzi IE.Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-bindingprotein human antigen R (HuR). Journal of Biological Chemistry . 2010
  • 10Elia,A.,Vyas,J.,Laing,K.G.,Clemens,M.J.Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1. European Journal of Biochemistry . 2004

二级参考文献2

共引文献4

同被引文献27

  • 1石华,宋方洲.双链RNA依赖性蛋白激酶的结构与作用[J].生命的化学,2006,26(1):38-41. 被引量：5
  • 2贾因棠,魏来,蒋栋,丛旭,费然.双链RNA激活的蛋白激酶(PKR)的克隆表达及其对丙型肝炎病毒蛋白合成的抑制作用[J].中国生物化学与分子生物学报,2006,22(1):24-30. 被引量：3
  • 3石巧荣,田进文,王丽英.2型糖尿病与炎症及抗炎治疗进展[J].实用医学杂志,2007,23(15):2289-2291. 被引量：12
  • 4Colli ML,Nogueira TC,Allagnat F,et al. Exposure to the viral by-product dsRNA or Coxsackie virus B5 triggers pancreatic beta cell apoptosis via a Bim/Mcl-1 imbalance [ J ]. PLoS Pathog, 2011,7 (9) : e 1002267.
  • 5Dharel N, Kato N, Muroyama R, et al. Potential contribu- tion of tumor suppressor p53 in the host defense against hepatitis C virusEJ]. Hepatology, 2008,47 (4) : 1136-1149.
  • 6Der SD,Yang YL,Weissmann C, et al. A double-stranded RNA activated protein kinase-dependent pathway medi- ating stress-induced apoptosis[J].Proc Natl Acad Sci US- A, 1997,94(7) :3279-3283.
  • 7Jacob S,Deyo DJ,Cox RA,et al. Mechanisms of toxic smoke inhalation and burn injury:role of neutral en- dopeptidase and vascular leakage in mice [J]. Toxicol Mech Methods,2009, 19(3) : 191-196.
  • 8Masiello P. Animal models of type 2 diabetes with re- duced pancreatic beta-cell mass [J]. Int J Biochem Cell Biol, 2006,38(5-6) : 873-893.
  • 9Nakamura T,Furuhashi M,Li P,et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis [ J ]. Cell, 2010, 140 (3) :338-348.
  • 10Hu W,Hofstetter W,Wei X, et al. Double-stranded RNA- dependent protein kinase-dependent apoptosis induction by a novel small compound [J]. J Pharmacol Exp Ther, 2009,328(3) : 866-872.

引证文献3

二级引证文献5

现代肿瘤医学
2011年 第9期

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