中药所含三萜类化合物抗肿瘤活性及其作用机制的研究进展

Research advancement of the antitumor effect and mechanisms of triterpenoid comprised by traditional Chinese medicine

三萜类化合物是中药所含活性成分之一,其结构复杂类型众多,具有多种生物活性,抗肿瘤作用是其重要生物活性之一。它通过诱导肿瘤细胞凋亡及阻滞肿瘤细胞增殖周期进程而抑制肿瘤细胞增殖,同时还具有抗肿瘤细胞侵袭和转移、抑制肿瘤血管生成和阻抑肿瘤细胞端粒酶活性等作用。

Triterpenoid is one of active components of traditional Chinese medicine.It＇s chemcial constitution and category are very complicated.Antitumor is one of important active effects of triterpenoid.It＇s mechanisms of antitumor include induction of apoptosis,inhibition of proliferating cycle,inhibition of invasion and metastasis of tumor cells,antiangiogenesis,and inhibition of activity of telomerase.