可逆性后部白质脑病综合征的临床和影像学特征(附2例报告)

Clinical and imaging feature of reversible posterior leukoencephalopathy syndrome(report of 2 cases)

目的探讨可逆性后部白质脑病综合征(RPLS)的临床及影像学特点。方法回顾性分析2例RPLS患者的临床资料。结果 2例均为急性起病,例1为产后2 d出现持续高血压,以癫疒间发作、意识障碍为主要症状;例2遭雷击后出现以声音嘶哑、共济失调为主要症状。颅脑MRI检查急性期均显示以大脑后部为主的异常信号,恢复期异常信号可明显减少或消失。结论 RPLS临床表现为脑病的症状,急性期MRI的脑白质异常是可逆的。

Objective To approach the clinical and imaging features of reversible posterior leukoencephalopathy syndrome （RPLS）. Methods The clinical data of 2 RPLS patients were analyzed retrospectively. Results The onset of the 2 cases was acute. In case 1, the persistent hypertension was appeared in the 2 d after delivery, and the main symptoms were epileptic seizure and disturbance of consciousness. In case 2, the onset was after lightning strike and the main symptoms were hoarseness and ataxia. The MRI showed that the abnormal signal was located in the posterior of brain in acute stage, and which was decreased or disappeared in recovery phase. Conclusions The clinical feature of RPLS is the symptom of cerebrosis. The MRI abnormalities located in brain white matter at acute stage of RPLS is reversible.