血浆脂蛋白相关磷脂酶A2水平对进展性脑梗死的预测价值

Predictive value of plasma lipoprotein-associated phospholipase A2 in progressive cerebral infarction

目的研究血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平对进展性脑梗死的预测价值。方法采用双抗体夹心酶联免疫吸附法检测168例急性脑梗死患者和72名正常对照者的血浆Lp-PLA2水平。ACI患者每天进行美国国立卫生研究院卒中量表(NIHSS)评分,发病第3 d NIHSS评分比发病第1 d增加≥2分者为进展性脑梗死(进展性脑梗死组),<2分者为稳定性脑梗死(稳定性脑梗死组)。结果 168例ACI患者中进展性脑梗死40例,稳定性脑梗死128例。ACI组血浆Lp-PLA2水平明显高于正常对照组(P<0.01),进展性脑梗死组明显高于正常对照组及稳定性脑梗死组(均P<0.01);稳定性脑梗死组与正常对照组的差异无统计学意义。结论进展性脑梗死患者发病后血浆Lp-PLA2水平明显升高,其可能为早期预测进展性脑梗死发生的生物学指标。

Objective To study the predictive value of plasma lipoprotein-associated phospholipase A2 （Lp- PLA2） in progressive cerebral infarction. Methods Plasma Lp-PLA2 levels were detected by enzyme linked immunosorbent assay in 168 patients with acute cerebral infarction （ACI） and 72 normal controls. ACI patients were scoring by the National Institute of Health Stroke Scale（NIHSS） every day. The added value of NIHSS score≥2 in ACI patients between 3 d and 1 d indicated progressive cerebral infarction （ progressive cerebral infarction group） , and it indicated stable cerebral infarction （ stable cerebral infarction group） when the added value 〈 2. Results The 40 cases were progressive cerebral infarction and 128 cases were stable cerebral infarction in 168 ACI patients. The level of plasma Lp-PLA2 in ACI group was significant higher than normal control group （P 〈 0. 01 ）; which in progressive cerebral infarction group was significant higher than normal control group and stable cerebral infarction group （all P 〈 0. 01 ）. There was no statistic difference between the stable cerebral infarction group and normal control group. Conclusions The level of plasma Lp-PLA2 is significant higher in progressi,/e cerebral infarction patients, which may serve as a predictive biological indicator of progressive cerebral infarction in early stage.