背向散射积分对慢性肝炎肝纤维化检测的研究

Application of ultrasonic integrated backscatter tissue characterization in chronic viral hepatitis with liver histological fibrosis

目的:讨论背向散射积分(integrated backscatter,IBS)超声组织定位对慢性病毒性肝炎肝纤维化程度定量分析的临床应用价值。方法:应用HP5500彩色超声仪,分别检测30例慢性病毒性肝炎患者和64例正常人的肝脏近场、中场、远场的IBS值。结果:慢性病毒性肝炎肝组织的IBS值分别为:近场31.2±3.4 dB,中场36.9±3.5 dB,远场32.3±2.6 dB,正常对照组肝组织的IBS值分别为近场24.1±4.3 dB,中场20.9±5.0 dB,远场14.8±3.5 dB,二者间有显著差异(P<0.01);与病理诊断对比,IBS值随肝纤维化程度的加重而增大,轻、中、重度肝纤维化之间对比均存在差异(P<0.05)。结论:背向散射积分值能反映慢性病毒性肝炎肝纤维化的程度,对慢性肝病的诊断有一定的临床意义。

Objective：To evaluate the ultrasonic integrated backscatter in diagnosis of chronic viral hepatitis with histological fibrosis and to identify its fibrosis degree.Methods： IBS of near field,middle field and far field in liver of 30 patients with chronic viral hepatitis and histological fibrosis and 64 cases of normal controls were examined by HP Sonos 5500.Results： IBS of chronic viral hepatitis with liver histological were 31.2±3.4dB in near field,36.9±3.5dB in middle field,32.3±2.6dB in far field,all significantly higher than those of controls（near field 24.1±4.3dB,middle field 20.9±5.0dB,far field 14.8±3.5dB）（P0.01）;IBS had significant correlation with the histological fibrosis degrees（P0.05）.Conclusion： Ultrasonic integrated backscatter was sensitive in evaluating of liver fibrosis degree and was useful in clinical diagnosis of liver diseases.