小肾癌4D THRIVE动态增强扫描参数与肿瘤血管生成的相关性研究

Small renal cell carcinoma 4D THRIVE dynamic enhanced scanning parameters and the correlation with tumor angiogenesis

目的:探讨小肾癌4D THRIVE动态增强扫描参数与肿瘤血管生成的关系。方法:对30例临床疑似小肾癌患者进行4D THRIVE动态增强扫描,分别计算肿瘤感兴趣区(ROI)及瘤周正常肾组织的动态增强参数:最大增强斜率(Smax)、增强峰值(PH)及峰值时间(Tpeak)。病理标本进行免疫组织化学染色,测定微血管密度(MVD)计数和血管内皮生长因子(VEGF)表达,评价小肾癌各动态增强参数与MVD、VEGF的相关性。结果:小肾癌动态增强参数Smax(r=0.707,P<0.01)、PH(r=0.687,P<0.01)与MVD表达呈正相关,Tpeak(r=-0.413,P<0.05)与MVD表达呈负相关。小肾癌MVD计数(63.07±14.73)个/视野,高于瘤周正常肾组织(P=0.002);67%(20/30)的小肾癌VEGF表达阳性,高于瘤周正常肾组织(P=0.001)。结论:小肾癌4D THRIVE动态增强扫描部分参数与MVD、VEGF相关,在评价小肾癌血管生成方面有重要价值。

Objective： To investigate the relationship of small renal cell carcinoma 4D THRIVE dynamic enhanced parameters and tumor angiogenesis.Methods： Thirty cases clinically suspected small renal cell carcinoma patients were examined by 4D THRIVE dynamic enhanced scanning,tumor area of interest ROI and tumor-adjacent kidney tissues of dynamic enhanced parameters： the biggest enhanced slope（Smax）,peak height（PH） and time-to-peak（Tpeak） were calculated respectively.Pathologic specimens were performed by immunohistochemical staining,microvascular density（MVD） count and vascular endothelial growth factor（VEGF） expressing were examined,small renal cell carcinoma of each dynamic enhance parameters were correlated with MVD and VEGF.Results： The enhancement parameters Smax（r=0.707,P0.01）,PH（r=0.687,P0.01） correlated positively with MVD.Tpeak（r=-0.413,P0.05） correlated negatively with MVD.The mean value of MVD（63.07±14.73） field in patients with small renal cell carcinoma were siginificantly higher than tumor-adjacent kidney tissues（P=0.002）,67%（20/30） small renal cell carcinoma VEGF expression was positive,higher than tumor tumor-adjacent kidney tissues（P=0.001）.Conclusion： Small renal cell carcinoma 4D THRIVE dynamic enhanced scanning,some parameters correlated positively with MVD,VEGF.It has an important value in small renal cell carcinoma angiogenesis.