胃癌患者血脂变化及总胆固醇的临床意义

Clinical significance of lipids changes and total cholesterol in gastric carcinoma

目的测定胃癌患者血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的含量,探讨胃癌患者血清TC水平与胃癌临床病理特征之间的关系。方法采用日立7600-120E全自动生化分析仪检测157例胃癌、130例胃溃疡患者及64例正常人外周血血脂及脂蛋白。用酶法测定血清TG和TC,用沉淀法测定血清HDL和LDL。结果正常人组血清TG和TC分别为(1.59±0.81)mmol/L和(4.65±0.87)mmol/L,明显高于胃癌组的(1.43±0.66)mmol/L和(4.35±0.82)mmol/L及胃溃疡组的(1.53±0.63)mmol/L和(4.43±1.14)mmol/L,其中正常人组与胃癌组血清TC比较,差异有统计学意义(P<0.05);正常人组血清HDL和LDL分别为(1.30±0.36)mmol/L和(2.73±0.66)mmol/L,明显高于胃癌组的(1.10±0.27)mmol/L和(2.27±0.57)mmol/L及胃溃疡组的(1.13±0.31)mmol/L和(2.45±1.04)mmol/L,差异均有统计学意义(P<0.05)。胃癌患者血清TC水平与性别、年龄、肿瘤大小和浸润深度无关,与淋巴结转移、组织学类型及TNM分期有关(P<0.05)。结论测定胃癌患者血清TG、TC、HDL及LDL水平有助于判断胃癌患者的病程及预后。

Objective To survey the content of serum triglyceride （TG）, total cholesterol（TC）, high density lipoprotein （HDL） and low density lipoprotein （LDL） in patients with gastric cancer and gastric ulcer and to investigate the correlation between the level of TC and clinical parameters of gastric cancer. Methods The blood lipids and lipoproteins of 157 cases of gastric cancer, 130 cases of gastric ulcer patients and 64 cases of normal subjects were detected by the Hitachi 7600-120E automatic biochemical analyzer. The contents of serum TG and TC were surveyed by enzymic method, and the contents of HDL and LDL were surveyed by precipitation method. Results The contents of serum TG and TC in the group of normal subjects were （ 1.59±0. 81 ）mmol/l, and （4. 65±0. 87 ）mmol/L, which were higher than （ 1.43±0. 66 ）mmoL/L and （4.35±0. 82 ）mmol/L in gastric cancer group and （ 1.53±0. 63 ） mmol/L and （4. 43 ±1.14）mmol/L in gastric ulcer group, and the content of serum TC in the group of normal subjects was significantly higher than that in the group of gastric cancer （P 〈 0. 05 ）. The contents of HDL and LDL in the group of normal subjects were （1.30±0. 36）mmol/L and （2.73±0. 66） rnmol/L, which were significantly higher than （ 1. 10±0. 27）mmol/I, and （2.27±0. 57） mmol/L in gastric cancer group, and （ 1. 13±0. 31 ） mmol/L and （2. 45±1.04） mmol/L in gastric ulcer group （ P 〈 0.05 ）. The level of serum TC had no correlation with gerder, age, tumor size and invasive depth（ P 〉 0. 05 ）, but closely related to lymph node metastasis, histological type and TNM stage（P 〈 0. 05）. Conclusion Detection of the contents of serum TG, TC, HDL and LDL in patients with gastric cancer will be beneficial to the judgment of the course and prognosis of gastric, carcinoma.