甲氨蝶呤柱撑水滑石超分子结构层柱材料的插层组装

Intercalation and assembly of supramolecular materials of methotrexate pillared layered double hydroxides

用共沉淀和离子交换法将抗肿瘤类药物甲氨蝶呤(MTX)插层组装到水滑石层间,制备了一种新型的结晶度高、晶相单一且MTX在层间有序排列的超分子结构的药物-无机复合层柱材料.用XRD、原子光谱、元素分析、FT/IR、SEM及TG-DSC分析表征了超分子结构层柱材料的结构,并给出其结构模型.

A new drug-inorganic composite involving an antitumor compound methotrexate intercalated layered double hydroxides was assembled with coprecipitation and ion-exchange methods,from which high crystallized supramolecular materials wer eobtained and methotrexate were ordered between layers without impurities.The structures of supramolecular materials were characterized by powder X-ray diffra ction,atom absorbed spectra,FT-IR spectra,scanning electron microscope and TGDSC and the structure models were Suggested.