新生儿缺氧缺血性脑病S-100β蛋白表达的临床意义研究

Clinical Significance of serum S-100β determination in neonates with hypoxic-ischemic encephalopathy

目的探讨缺氧缺血性脑病(HIE)患儿血清S-100β蛋白水平检测的临床意义。方法用酶联免疫吸附法(ELISA)检测70例HIE新生儿和60例同期住院上呼吸道感染新生儿血清S-100β蛋白水平。结果中度和重度HIE新生儿血清S-100β蛋白含量水平较对照组明显升高,重度组S-100β蛋白含量水平较轻中度组增高,轻度组与对照组比较血清S-100β蛋白含量水平不升高。结论 S-100β蛋白可作为脑损伤的生化标志物,能反映疾病的严重程度,对临床有很好的参考价值。

Objective To investigate the clinical significance of the change of S-100β level in neonates with hypoxic-ischemic encephalopathy（HIE）.Methods Serum S-100β levels were determined in 70 neonates with HIE and 60 controls with upper respiratory infection by ELISA.Results Serum S-100β levels of HIE groups with severe and moderate were significantly higher than that in the controls,and S-100β level in severe group was higher than that in moderate group.There was no difference between mild level HIE group and control group.Conclusions Serum S-100β protein,responding to the severity of HIE,can be used as a biochemical marker in neonate brain injury.