特质焦虑和防御功能对抗抑郁药疗效的影响

The effects of trait anxiety and defensive function on antidepressant treatment outcome

目的研究特质焦虑与防御功能之间的关系,以及两者协同作用对抗抑郁药治疗效果的影响。方法选取102例首发的抑郁症病人,给予艾司西酞普兰治疗,应用17项汉密尔顿抑郁量表(HAMD-17)、状态-特质焦虑问卷(STAI)和88项防御方式问卷调查(DSQ-88),于治疗前后进行评分。结果最终有84例完成了本研究。特质焦虑分值较高和总体防御功能(ODF)水平低的病人,其最终的汉密尔顿抑郁量表的评分较高。结论高水平的特质焦虑与不成熟的防御功能协同作用,对抗抑郁药的疗效有明显的负性影响。

Objective To study the relationship between trait anxiety and defensive function, and their combined influence on response to antidepressants among inpatients with first depressive episode. Methods 102 inpatients with first depressive episode were treated by escitalopram, and wre assessed with HAMD -17 ,STAL and DSQ -88. Results The final sample has 84 inpatients. Those who had a high score on trait anxiety and a low score on ODF, had a significantly higher final scores on HAMD - 17. Conclusion The combination of a high level of trait anxiety and immature defensive function evidently had a negative effect on antidepressant outcome.