新生儿缺血缺氧性脑病早期干预及预后观察

Early intervention and prognostic analysis of hypoxic ischemic encephalopathy

目的分析研究早期干预治疗对新生儿缺血缺氧性脑病患儿预后的影响。方法收集我院2009年1月至2010年1月期间在我院治疗的68例新生儿缺血缺氧性脑病患儿。68例患儿随机分为干预组34例和对照组34例。对照组行常规治疗和护理,干预组除常规治疗和护理外,还进行药物、视觉、听觉、触觉刺激,3次/d,15～20min/次,连续治疗6个月。结果干预组患儿智能发育指数高于对照组(P<0.05)。两组患儿运动发育指数比较,干预组高于对照组(P<0.05);对照组34例患儿中,预后不良者16例,预后良好者18例;干预组34例,其中预后不良者9例,预后良好者25例,两组比较差异有统计学意义(P<0.05)。结论早期干预对缺血缺氧性脑病患儿智能上有促进作用,且能显著改善患儿的预后。

Objective To investigate the treatment of early intervention and prognosis on neonates with hypoxic ischemic encephalopathy （HIE）. Methods 68 newborn patients with HIE admitted in our hospital during January 2009 to January 2010 were randomly divided into intervention group and control group. Each group contained 34 cases. The control group underwent conventional treatment and nursing. The intervention group underwent conventional treatment, nursing care, Inedicine treatment, sense of sight, sense of heating and tactile stimulation with three times a day and 15-20 minutes per time. The patients were treated up to 6 months. Results Of the intervention group the average intellectual development index is higher than control group （ P 〈 0.05 ）. Comparing motor development index, the intervention group is significantly higher than the control group （ P 〈 O. 05 ）. There were significant differences for oceuring unfavourable prognosis between control group of 16 cases and intervention group of 9 cases （ P 〈 0. 05 ）. Conclusions HIE patients will benifit from early intervention in advancing intelligent and improving prognosis.