盐酸氨溴索联合地塞米松氧气雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察

Efficacy of Aerosol Inhalation of Ambroxol and Dexamethasone in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的观察盐酸氨溴索联合地塞米松氧气雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法将105例慢性阻塞性肺疾病急性加重期的患者随机分为治疗纽（58例）和对照组（47例）。对照组予以低流量吸氧、支气管舒张剂舒张支气管、敏感抗生素抗感染及对症处理，治疗组在此基础上加用盐酸氨溴索15mg、地塞米松5mg、注射用水4ml混合氧气雾化吸入，每天2次，每次15分钟，7天为1疗程。评价两组的临床疗效。结果治疗组在总有效率、咳嗽好转时间、肺部罗音消失时间及住院时间等方面均优于对照组（P〈0．05）．结论盐酸氨溴索联合地塞米松氧气雾化吸入可提高慢性阻塞性肺疾病急性加重期的临床疗效。

Objective To observe the effect of Ambroxol Hydrochloride and dexamethasone in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods 105 cases of acute exacerbation of chronic obstructive pulmonary disease were divided into treatment group and contrast group randomly. Both of the groups received bronchodilatation agent and antibiotics. But added Ambroxol Hydroehloride and dexamethasone in treatment group. The clinic outcome of total response rate, time in hospital and the speed of relieving cough of the two groups were observed and evaluated. Results There were exact statistics signifieances between the treatment group and contrast group in total response rate, time in hospital and the speed of relieving cough （P〈0.05）. Conclusion It can improve the clinic outcome in the treatmetn of acute exacerbation of chronic obstructive pulmonary disease that use aerosol inhalation of Ambroxol and dexamethasone.