结直肠高危腺瘤的危险因素分析

Analysis of risk factors for high-risk colorectal adenomas

目的回顾分析有病理诊断的结直肠腺瘤,寻找与结直肠高危腺瘤相关的因素。方法回顾统计结直肠腺瘤病例共124例,分析吸烟、饮酒及合并高血压、冠心病、糖尿病、高脂血症与结直肠高危腺瘤的相关关系。结果高脂血症患者患结直肠高危腺瘤的危险度是非高脂血症患者的3.26倍。多因素Logistic回归分析显示性别、吸烟、饮酒、高血压、冠心病未进入方程,能够独立影响结直肠高危腺瘤的危险因素有年龄(OR=1.06,P=0.008)、糖尿病(OR=5.35,P=0.028)、高脂血症(OR=5.92,P<0.000 1)。结论年龄、糖尿病、高脂血症可增加患结直肠高危腺瘤的风险。

Objective To explore the risk factors for high-risk colorectal adenomas.Methods Data of 124 patients with colorectal adenomas were retrospectively analyzed.The relations between high-risk colorectal adenomas and history of hypertension,coronary artery disease,diabetes mellitus,hyperlipidemia and life style such as smoking and alcohol intake were assessed by Logistic regression and Chi-square.Results The risk of developing colorectal high-risk adenomas had a 3.26-fold increase in patients with hyperlipidemia compared to those without hyperlipidemia.The incidence of high-risk colorectal adenomas was significantly related to age（OR=1.06,P=0.008）,history of diabetes mellitus（OR=5.35,P=0.028） and hyperlipidemia（OR=5.92,P0.000 1）,but not to sex,smoking,alcohol intake,hypertension and coronary artery disease.Conclusion Age,diabetes mellitus and hyperlipidemia could increase the risk of developing high-risk colorectal adenomas.