轮状病毒肠炎患儿血清微量元素变化及与病情的关系研究

Changes of serum trace elements in children with rotavirus enteritis and its relationship with disease

目的:了解轮状病毒肠炎患儿锌、铁、铜、钙、镁、锰、铅等微量元素状况。方法:随机选取173名轮状病毒肠炎患儿纳入研究,同时选择同期保健门诊健康儿童作为正常对照组,分别测定研究对象血清锌、铁、铜、钙、镁、锰、铅等的水平。结果:轮状病毒肠炎组患儿血清锌、铁、铜、钙、镁以及锰的水平显著低于正常对照组患儿(P<0.05),但是血清铅水平则无明显组间差异(P>0.05)。轮状病毒肠炎患儿血清锌、铁以及钙的水平与Vesikari病情评分呈显著负相关(P<0.05),而铜、镁、锰和铅水平则与病情评分无显著相关性(P>0.05)。结论:轮状病毒肠炎患儿可能存在常见微量元素代谢的改变,临床工作中需要对该类患儿进行微量元素监测。

Objective： To explore the changes of serum trace elements, such as zinc, iron, copper, calcium, magnesium, manganese and lead in children with rotavirus enteritis and its relationship with disease. Methods： About 173 children with rotavirus enteritis from the department of hospital were randomly selected into the study and 173 healthy children over the same period were as the control group. The levels of serum zinc, iron, copper, calcium, magnesium, manganese and lead were measured, respectively. Results： The levels of serum zinc, iron, copper, calcium, magnesium and manganese from children with Rotavirus enteritis were significantly lower than those of control group （P 〈0.05）, but no significant difference of serum lead between the two groups was found （P 〉 0.05） . The levels of serum zinc, iron, and calcium from children with Rotavirus enteritis had significantly negative correlation with Vesikari illness score （P 〈 0.05 ）, but not for copper, magnesium, manganese and lead levels （P 〉 0.05）. Conclusion： There may be uncommon enteritis trace element metabolism in children with rotavirus enteritis and trace elements level needed to be monitored for children with such disease in clinic work.