大蒜对食管癌前病变的影响及与免疫关系的实验研究

EXPERIMENTAL STUDY OF BULBUS ALLII ON EFFECT OF PRECANCEROUS LESIONS OF ESOPHAGUS AND RELA-TION WITH IMMUNITY OF IT IN RATS

本文旨在研究大蒜对食管癌的预防作用。选用Wistar大鼠84只,皮下注射1％甲基戊基亚硝胺溶液5mg/kg,每周一次。给此致癌药前,实验组大鼠用50％大蒜液灌胃,10m1/kg,每周六次;对照组给等量生理盐水。105天后,发现大蒜对甲基戊基亚硝胺诱发大鼠食管癌前病变具有显著抑制作用(P<0.05),增加脾脏指数(P<0.001)和外周血T淋巴细胞百分率(P<0.01)。结果提示大蒜具有预防食管癌作用,可能与它的增强免疫作用有关。

This paper is for studying Bulbus Allii on the preventive effect for carcinoma of the esophagus. The test carried out in 84 Wistar rats, every one was injected by hypodermic injection 1％ solution of N-methyl-N-amylnitrosamine (MANA) 5mg/kg once a week. Before given carcinogen, each rat of the test group (n-42) was administered per cs 50％ aqueous extract of Bulbus Allii 10ml/kg six times a week. The control group (n=42) was given per cs physiological saline, the dose was same as above. After the 105th day of experiment, Bulbus Allii is found to exert a significant inhibitory effect on precancerous lesions of esophagus of MANA(p<0.05), but the splenic index (p<0.001) and the percentage of T-lymphocyte (p<0.01) increase in rats. The results suggest that Bulbus Allii haye a preventive effect for the carcinoma of esophagus and the effect could relate wilh increasing the action of immunity of it.