免疫调理治疗对恶性梗阻性黄疸术后感染并发症的防治

PREVENTION AND CURE EFFECT OF IMMUNOREGULATION THERAPY ON POSTOPERATIVE INFECTIOUS COMPLICATIONS OF MALIGNANT OBSTRUCTIVE JAUNDICE

目的探讨免疫调理治疗对恶性梗阻性黄疸病人术后感染并发症的防治作用及作用机理。方法对2005年5月~2010年7月我院经手术治疗的126例恶性梗阻性黄疸的患者资料进行回顾性总结分析,按治疗方式分为治疗组（58例）和对照组（68例）。治疗组在手术治疗的基础上加用胸腺肽α1及乌司它丁（免疫调理治疗）,免疫调理疗程为7 d,观察2组患者血淋巴细胞变化以及术后感染的发生率。结果治疗组发生感染并发症10例,发生率17.2%（10/58）,对照组发生感染并发症23例,发生率33.8%（23/68）。两组感染并发症发生率差异具有显著性差异（P〈0.05）。术后第3、5、7、14天血淋巴细胞计数对照组明显低于治疗组（P〈0.05）。结论免疫调理治疗可有效降低恶性梗阻性黄疸术后感染并发症发生率及死亡率。

Objective To study the prevention and cure effect of immunoregulation therapy on postoperative infectious complications of malignant obstructive jaundice.Methods We retrospectively analysised 126 cases of malignant obstructive jaundice who underwent surgery during May 2005 to July 2010,according to treatment into treatment group（58 cases） and control group（68 cases）.Thymosin-α1 plus ulinastatin were used in the treatment group for 1 week on the basis of operation.The changes in lymphocyte count and the incidence of postoperative infection were observed.Results The incidence of postoperative infectious complications in treatment group,17.2%（10/58） was remarkable lower than that in control group（33.8%,23/68,P0.05）.The level of lymphocyte count in treatment group was remarkable lower than that in control group during the 3rd,5th,7th and 14th（P0.05）.Conclusion Immunoregulation therapy could effectively reduce the malignant obstructive jaundice complication rate of postoperative infection and mortality.