罗库溴铵用于紫绀型先天性心脏病患儿临床药效观察

Clinical Observation on the Clinical Pharmacodynamics of Different Doses of Rocuronium in Children with Cyanotic Congenital Heart Disease

【目的】观察不同剂量罗库溴铵用于紫绀型先天性心脏病的临床药效。【方法】选择紫绀型先心病患者56例，轻度紫绀与重度紫绀患者各28例；根据诱导后给予不同剂量罗库溴铵随机分为低剂量组（0．6mg／kg），高剂量组（0．9mg／kg），测定罗库溴铵的起效时间、作用时间及恢复指数。【结果】与轻度紫绀组比较，重度紫绀组的起效时间延长（P〈0．05），而作用时间和恢复指数差异无统计学意义；与低剂量相比较，高剂量组（0．9mg／kg）罗库溴铵起效时间减少，作用时间延长，差异有统计学意义（P〈0．05）。【结论】不同剂量罗库溴铵对紫绀型先心病患儿敏感性不一致，重度紫绀型先心病患儿罗库溴铵的起效时间延长。

[Objective] To observe the clinical pharmacodynamics of different doses of rocuronium in children with cyanotic congenital heart disease. [Methods] Totally 56 patients with cyanotic congenital heart disease including 28 patients with mild cyanosis and 28 patients with severe cyanosis were chosen. According to the different dosage of rocuronium after induction, all patients were divided into low dosage group（0.6mg/kg） and high dosage group（0.9mg/kg）. The onset time, clinical duration and recovery index were observed. [Results] Compared with mild cyanotic group, the onset time in severe cyanotic group increased（ P 〈0.05）, but there was no significant difference in the clinical duration and recovery index between them. Compared with low dosage group, the onset time decreased and the clinical duration increased in high dosage group, and there was significant difference between them（ P 〈0.05）. [Conclusion] Different doses of rocuronium in children with cyanotic congenital heart disease have different sensitivity. The onset time of rocuronium in children with severe cyanotic congenital heart disease is longer.