CRRT中不同治疗剂量对血小板数量的影响

Effects of Different Doses in Continuous Renal Replacement Therapy on the Number of Platelets

目的探讨在CRRT治疗中不同治疗剂量对血小板数量的影响。方法对36例需行CRRT治疗的患者分为传统治疗剂量组和低治疗剂量组,选择相同的滤器,观察治疗前后血小板的数量、肾功能的指标及C-反应蛋白的变化,应用统计学方法进行分析不同治疗剂量对上述指标的影响有否差异。结果低治疗剂量组对血小板数量影响比传统治疗剂量组小,且能降低肌酐及尿素氮,但不能降低C-反应蛋白。结论 CRRT中低治疗剂量对血小板数量影响小,可用于肾功能衰竭伴血小板减少需行CRRT治疗的危重症患者。

Objective To study the effects of different doses in continuous renal replacement therapy （ CRRT ） on number of platelets. Methods All 36 patients who required CRRT were included in the study and were randomly divided into the traditional dose group and the low dose group. Both groups choosed the same filters. The number of platelets, urea nitrogen （ UN ）, creatinine （ Cr ） and CRP of both groups evaluated before and after CRRT were compared and studied. Results The low dose in CRRT had less impact on the number of platelets than the traditional dose, and it could reduce the level of UN and Cr, but it could not reduce the level of CRP. Conclusion The low dose in CRRT has less impact on the number of platelets. It can be used for patients who have renal failuer with thrombocytopenia required for CRRT.