摘要
晶状体规则有序的组织结构和独特的生理学特点决定其透明性,并起到消除光散射及优化光学特性的作用。最近研究表明晶状体内离子内流和外流途经的空间差异性及相互作用参与其容积调节,以应对细胞低渗透压性肿胀及纤维组织分化。因此保持晶状体透明有赖于细胞及组织层面上对容积变化的调节能力,无论细胞肿胀还是细胞间间隙扩张均可导致透明纤维束断裂,不仅破坏规则的细胞排列方式,也改变晶状体蛋白溶解度,产生光散射并最终导致白内障。
出处
《国际眼科纵览》
2011年第4期250-253,共4页
International Review of Ophthalmology
参考文献27
-
1Bhat SP. The ocular lens epithelium. Biosci Rep, 2001,21 : 537- 563.
-
2Tim TJ, Jacob T. The relationship between cataract, cell swelling and volume regulation. Prog Retin Eye Res, 1999, 18: 223-233.
-
3Candia O. Electrolyte and fluid transport across corneal conjuncti- val and lens epithelia. Exp Eye Res, 2004, 78: 527-535.
-
4Robinson KR, Patterson JW. Localization of steady currents in the lens. Curr Eye Res, 1982, 2: 843-847.
-
5Candia OA, Zamudio AC. Regional distribution of the Naand Kcurrents around the crystalline lens of rabbit. Am J Physiol, 2002, 282 : 252-262.
-
6Mathias RT, Rae JL, Baldo GJ. Physiological properties of the normal lens. Physiol Rev, 1997, 77: 21-50.
-
7Kistler J, Eckert R, Donaldson PJ. Lens membranes. In: Lens development. Cambridge, UK : Cambridge University Press, 2004 : 151-172.
-
8Delamere NA, Tamiya S. Expression, regulation and function of Na, K ATPase in the lens. Prog Retin Eye Res, 2004, 23: 593- 615.
-
9Chee KN, Kistler J, Donaldson PJ. Roles for KCC transporters in the maintenance of lens transparency. Invest Ophthalmol Vis Sci, 2006, 47 : 673-682.
-
10Webb KF, Merriman-Smith BR, Stobie JK, et al. Cl-influx into rat cortical lens fiber cells is mediated by a Cl-conductance that is not ClC-2 or -3. Invest Ophthalmol Vis Sci, 2004, 45: 4400- 4408.
同被引文献15
-
1Pasantes-Morales H, Lezanm RA, Ramos-Mandujano G. Mechanisms of cell volume regulation in hypo-osmolalily[J]. Am J Med,2006,119(7 Suppl 1) :S4-11.
-
2Bortner C D,Cidlowski JA. C shrinkage and montJvaleut catitm fluxes: role in apoptosis[ J ]. Arch tlioetu, m Biophys,2007,462 : 176-188.
-
3Hoffnumn EK, l,ambert IH, Pedersen SF. Physiology of cell w lumc regulati:m in vertebrates[ J ]. Physiol Rev ,2009,89 : 193-277.
-
4Bachmann O,Heinzmann A.Maek A,et al. Mechanisms of secret ion- associated shrinkage and volume recovery, in cultured rabbit parietal cells[ J ]. Am J Physiol Gastrointest l,ivcr Physiu1,2007 ,292 : 711-717.
-
5Suleymanian MA, Baumqarten CM. Osmotic gradient-induced water permeation actress the sarc:lemma of rabbit ventricular myocytes [ J ]. J G:,n Physiol, 1996,107 : 503-514.
-
6Mongin AA, Orlov SN. Mechanisms of cell volume regulation andpossible nature of" the cell w:lume sensor[ J]. Pathophysiology,2001,8 : 77 -88.
-
7Fu W J, Kuwahara M, Marumo F. Mechanisms of regulatory' volume decrease in collecting duct cells[ J]. Jtm J Physiol,1995,45:97-11)9.
-
8Adoranh- JS, Caia PM. Mechanisms of regualatory volume decrease in nonpigmented Imman ciliary epithelial cells [ J ]. Am J Physiol, 1995, 268(3 Pi 1) :C721-731.
-
9Pearlman DF, Musch MW, Goldstcin L. Cellmembrane surface expression and tyr.sine kinase regulate the osm.lytc channel( skAE1 )in skate erythr.eytes[ J ]. Aeta Physio1,2(106,187 : 87-91.
-
10Mathias RT, Riquelme G,Rae JL. Cell t, cell c.mmunication and pH in the frog lens[ J]. J Gen Physiol,1991.98:1085-1103.
-
1杨毅,陈晓明,冷麟.白内障与晶状体的离子转运[J].生物化学与生物物理进展,1990,17(1):30-32.
-
2余超明,梁伟亮,关仕嫦,关卫文,黄泳瑜.难治性青光眼合并白内障的手术干预[J].中国社区医师(医学专业),2010,12(30):92-92.
-
3程序,徐亮,李辽青,陈长喜.鸡形觉剥夺性近视眼视网膜光镜下形态改变[J].眼科,2000,9(2):108-109. 被引量:5
-
4张敏华,庄晓东,翁景宁.容积调控性氯通道与晶状体后囊膜混浊发病机制的关系[J].国际眼科纵览,2012,36(6):428-432.
-
5刁肇明.论渐进多焦点镜片的验配[J].中国眼镜科技杂志,2003(2):24-25. 被引量:1
-
6张庆慧,杨娅,王蕊.医院、幼儿园联合治疗儿童弱视的疗效探讨[J].国际眼科杂志,2009,9(5):994-995. 被引量:14
-
7王卫群,杨应琴,刘欢,田英,张改玲,张晓兰,张幼梅.新型眼前段分析系统测量LASIK术后角膜及前房变化[J].中华眼外伤职业眼病杂志,2016,38(2):81-85. 被引量:1
-
8翁景宁,朱建琼.5-氟尿嘧啶在青光眼小梁切除中的应用[J].福建医科大学学报,1999,33(2):216-216.
-
9张颖洁,周激波.视网膜色素上皮细胞在近视发病机制中的作用[J].中华眼视光学与视觉科学杂志,2015,17(9):573-576. 被引量:1
-
10陈锦礼.层间巩膜瓣嵌置合并咬切术治疗近绝对期青光眼(附69例报告)[J].临床眼科杂志,1994,2(2):84-85.