华中五味子化学成分的研究

Studies on Chemical Constituents of Schisandra sphenanthera Rehd. et Wils.

目的对传统中药华中五味子中的化学成分进行初步研究。方法运用多种色谱方法分离纯化,通过现代波谱解析技术(如NMR和MS等)和理化数据的文献对照,鉴定结构。结果与结论从华中五味子中分离得到了10个化合物,分别鉴定为五味子酚(schisanhenol,1)、五味子酯乙(schisantherin B,2)、chicanine(3)、pregomisin(4)和甘五酸(schizandronic acid,5)、去氧五味子素(6)、前戈米辛(7)、内消旋二氢愈创木脂素(8)、五味子酯甲(9)、戈米辛P顺芷酸酯(10)。首次从该植物中分离得到化合物前戈米辛(7)。

Objective To study the chemical constituents of Schisandra sphenanthera Rehd. et Wils. Methods The constituents of Schisandra sphenanthera Rehd. et Wils were isolated by classics phytochemistry research technique and variety of chromatographies over various materials. Results and Conclusion Ten compounds were isolated from Schisandra sphenanthera Rehd.et Wils.They were identified as chisanhenol（1）, schisantherin B（2）, chicanine（3）,pregomisin（4）,and schizandronic acid（5）, deoxyschisandrin （6）,progomisin （7）, meso-dihydroguaiaretic acid （8）, schisantherin A （9）, tigloylgomisin （10）.Compounds7 was obstained from this plant for the first time.