可吸收性脊柱椎间融合器的理论研究与临床应用

Research development of the bioresorbable intervertebral fusion cage

背景:生物可吸收椎间融合器材料具有与骨组织相似的强度及弹性模量,具有射线可透过性,且能随着时间推移逐渐被人体组织吸收替代并更易于融合。目的:介绍各种可吸收性椎间融合器材料的特点、动物实验以及临床应用效果。方法:主要选择被PubMed收录的外文文献和在国内核心杂志上发表的有关可吸收性椎间融合器的文献,就其内容进行分析、分类、归纳及总结。结果与结论:尽管可吸收材料椎间融合器相对于传统椎间融合器来说具有许多优点,目前的实验研究和临床使用也取得了比较满意的结果,但其材料本身属性所致的风险仍然不可忽视,比如pH值降低、存在产生无菌性炎症反应和局部骨吸收的危险等。另外大多数聚合物材料脆性高,由其加工制成的融合器置入人体后可能出现融合器断裂,导致融合失败,尚需逐步发展完善。

BACKGROUND：Bioabsorbable intervertebral fusion cage has similar strength and modulus of elasticity with bone tissues and possesses ray permeability. It can be absorbed gradually by human tissues which is apt to fusion. OBJECTIVE：To introduce the characters in different materials of the bioresorbable intervertebral fusion cage,illustrate results of animal researches and investigate effects of different fusion cages in clinical application. METHODS：Literatures about the bioresorbable intervertebral fusion cage published in English and those published in domestic core magazines were selected from PubMed,and those articles were analyzed,classified,summarized and reviewed. RESULTS AND CONCLUSION：With the development of materials science,absorbing materials in spinal surgery are widely applied. Although they have shown remarkable clinical result and prospect as an emerging technology,they still need to be gradually developed,and more research should be carried out.