妊娠期高血压疾病中血清VEGF与PLGF水平的作用研究

Role of VEGF and placenta growth factor in the pathogenesis of hypertensive disorder complicating pregnancy

目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)与胎盘生长因子(placenta growth factor,PLGF)在妊娠期高血压疾病(hypertensive disorder complicating pregnancy,HDCP)发病中的作用。方法采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测38例正常妊娠及41例妊娠期高血压疾病患者血清VEGF与PLGF水平。结果与正常妊娠组比较,分娩前妊娠期高血压疾病组血清VEGF与PLGF水平明显降低,有显著性差异(P<0.05);分娩后妊娠期高血压疾病组血清VEGF与PLGF水平无显著性差异(P>0.05)。结论妊娠期高血压疾病患者血清VEGF与PLGF水平降低可以导致胎盘浅表着床,是妊娠期高血压疾病影响胚胎发育的重要作用机制之一。

Objective To investigate the role of vascular endothelial growth factor （VEGF） and placenta growth factor （PLGF） in the pathogenesis of hypertensive disorder complicating pregnancy （HDCP）. Methods Forty-one patients with HDCP and thirty-eight normal late pregnant women were observed. Enzyme-linked immunosorbent assay （ELISA） was performed to examine serum concentrations of VEGF and PLGF. Results The serum levels of VEGF and PLGF were significantly lower in HDCP group compared with those in normal control group prior to birth （ P 〈 0. 05 ） ; and there was no significant difference between HDCP group and the normal control group after parturition （ P 〉 0. 05 ）. Conclusion The serum levels of VEGF and PIGF are significantly lower in HDCP, which lead to superficial implantation and may be one of the important mechanisms involved in the effects of HDCP on embryonic development.