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Brd4、P—TEFb及E2蛋白的相互作用及其与子宫颈癌变的关系 被引量：2

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摘要 宫颈癌是妇女除乳腺癌外最常见的恶性肿瘤，也是妇女主要的致死原因之一。高危型HPV持续感染是宫颈癌的重要危险因素。宫颈癌的发展过程是多种因素协同作用的结果，而HPV与宿主染色体的整合及相应的早期蛋白2（E2）基因完整性被破坏则是推动宫颈癌变进展的重要事件。目前，对宫颈癌的发病机制研究逐渐成为热点，溴化结构4（bromodomain4，Brd4）、
作者 徐志敏 时艳梅
机构地区 山东省烟台市烟台山医院妇科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2011年第8期636-638,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 子宫颈癌变 E2蛋白 相互作用 高危型HPV 恶性肿瘤 致死原因 危险因素 持续感染
分类号 R737.33 [医药卫生—肿瘤]
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参考文献18

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同被引文献14

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  • 10雷静,万霖,李惠新,蒋瑛,李瑞萍.薄层液基细胞学在宫颈癌及其癌前病变筛查中的价值[J].现代生物医学进展,2011,11(16):3123-3125. 被引量：6

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中华妇产科杂志
2011年 第8期

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