溃疡性结肠炎易感基因的研究进展

Genes associated with susceptibility to ulcerative colitis

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明的肠道慢性炎症性疾病,目前较为一致的观点认为,UC是携带易感基因的个体在环境因素的作用下,自身免疫功能紊乱所引发的一种肠道非特异性炎症性疾病.其发病的种族地理差异、单卵双生子的高共患率和家族聚集现象,提示遗传因素在UC发病中起重要作用.目前已发现许多UC相关基因及易感突变位点,本文就这些基因与UC遗传易感性关系的研究进展作一介绍.

Ulcerative colitis （UC） is a chronic intestinal inflammatory disease whose etiology is still un- known. It is widely believed that UC is a kind of non-specific inflammatory disease which is caused by environmental factors and autoirn- mune disorders in people who carry susceptibil- ity genes. Epidemiologic data, such as familial aggregation, twin studies, and racial/ethnic differences in disease prevalence, indicate that there are genetic contributions to UC pathogen- esis. In this article, we will review the recent progress in research of genes associated with susceptibility to UC.