肥大细胞在胃癌中的功能

Roles of mast cells in gastric carcinogenesis

肥大细胞在肿瘤发生发展中的作用得到越来越多的重视,但在胃癌中对肥大细胞的研究才刚起步.目前研究表明,肥大细胞在胃癌中的作用可以分为以下3个方面:(1)肥大细胞促进血管生成;(2)肥大细胞的免疫调节作用;(3)肥大细胞与组织重塑.这3方面均与肿瘤生长及转移密切相关.本文拟从此3方面对肥大细胞在胃癌中的研究进展进行综述,并介绍肥大细胞的调节性药物在肿瘤临床中的应用.

There is a growing acceptance that mast cells play an active role in tumor growth. However, little is known about the role of mast cells in gas- tric carcinogenesis. Accumulated evidence sug- gests that mast cells play critical roles in gastric carcinogenesis in terms of promoting angiogen- esis, modulating immune responses and par- ticipating in tissue remodeling. All these roles are closely related to tumor growth and metas- tasis. In this paper, we review recent advances in research on the roles of mast cells in gastric carcinogenesis. We also discuss the clinical ap- plication of drugs regulating mast cell function in tumors.