FHIT,Caspase-3及Survivin蛋白在结肠癌组织中的表达及其意义

Expressive significance of FHIT,Caspase-3 and Survivin protein in colon carcinoma

[目的]探讨结肠癌组织FHIT,Caspase-3及Survivin蛋白表达状况及其意义。[方法]免疫组化方法检测60例结肠癌组织和癌旁组织标本FHIT,Caspase-3及Survivin蛋白表达,并分析结肠癌3种蛋白表达间的相关性。[结果]结肠癌与癌旁组织,FHIT蛋白表达阳性率分别为31.9%和93.3%(P<0.05),Caspase-3蛋白表达阳性率分别为26.7%和85.0%(P<0.05),Survivin蛋白表达阳性率分别为81.7%和36.6%(P<0.05)。相关性分析结果显示:结肠癌组织FHIT蛋白表达同Caspase-3蛋白表达呈正相关关系(r=0.410,P=0.006),同Survivin蛋白表达呈负相关关系(r=-0.454,P=0.004)。[结论]结肠癌组织存在FHIT,Caspase-3蛋白表达缺失及Survivin蛋白过度表达。

[Objective] To investigate the significance of FHIT,Caspase-3 and Survivin expressions protein in colon carcinoma.[Methods] The expressions of FHIT,Caspase-3 and Survivin proteins in 60 colon carcinoma and para-carcinoma tissues were detected with immunohistochemistry.[Results] In carcinoma and para-carcinoma tissues,the positive expression rates of FHIT were 31.9% and 93.3% respectively（P〈0.05）,the rates of Caspase-3 were 26.7% and 85.0% respectively（P〈0.05）,while the rates of surviving were 81.7% and 36.6% respectively（P〈0.05）.There were positive correlation of FHIT protein expression to Caspase-3 protein（r=0.410,P=0.006）,but negative to Survivin（r=-0.454,P=0.004）.[Conclusion] There are loss expressions of FHIT and Caspase-3 proteins and overexpressions of Survivin protein in colon carcinoma.