摘要
背景:韧带和其他生物软组织一样,具有黏弹性特性,其应力松弛和蠕变黏弹性特性是为适应人的生理功能需要而存在的。研究说明骨性关节炎对韧带力学性能具有一定影响。目的:比较正常和骨性关节炎动物模型内侧副韧带的应力松弛流变特性,确定骨性关节炎对内侧副韧带应力松弛特性的影响。方法:以闭合关节刻痕法复制骨性关节炎动物模型,取正常和骨性关节炎动物模型大鼠膝关节内侧副韧带各10个试样,进行应力松弛实验。应力松弛实验的应变增加速度为5%/s。设定实验时间为7200s,采集100个数据,观察应力松弛数据和曲线、应力与时间的变化规律,以一元线性回归分析的方法处理实验数据。结果与结论:正常组和病态组试样应力松弛最初600s变化较快,之后应力缓慢下降,正常组7200s应力松弛量0.47MPa,病态组7200s应力松弛量0.29MPa。模型组7200s应力松弛量显著低于正常组(P<0.05),且应力松弛曲线是以对数关系变化的。说明骨性关节炎时可以使膝关节对内侧副韧带应力松弛量降低,对膝关节应力松弛特性具有一定影响。
BACKGROUND:Similar to other soft tissues,ligament has viscoelasticity.The stress relaxation and creep viscoelasticity of ligaments are based on human physiologic functions.Studies have demonstrated that osteoarthritis has effect on ligament mechanical property.OBJECTIVE:To compare stress relaxation rheological properties of medial collateral ligament(MCL) between normal and osteoarthritis animal models,to determine the influence of osteoarthritis on MCL ligament stress relaxation characteristics.METHODS:Animal osteoarthritis models were prepared by closed joint Nick method.Each 10 MCL samples were taken from normal and osteoarthritis rats for stress relaxation experiments.The strain increase rate was 5%/s,and test duration was 7 200 s,a total of 100 data were collected.The stress relaxation data,and change laws of curves,stress and time were observed.All data were analyzed by one linear regression.RESULTS AND CONCLUSION:The stress relaxation of the normal and model groups changed fast at the initial 600 s,followed by a slow decrease.The stress relaxation of the normal group at 7 200 s was 4.69 MPa,and the model group was 0.29 MPa.The 7 200 s stress relaxation quantity of the model group was obviously smaller than that of the normal group(P〈0.05).The stress relaxation curves were changed in a log relationship.The knee osteoarthritis can decrease MCL stress relaxation,which influences LCL stress relaxation characteristics.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第15期2707-2710,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research