纳米银材料在妇科疾病中的应用

Application of nano-silver materials in gynecological diseases

目的:分析比较纳米银凝胶对不同程度、不同类型阴道炎及宫颈糜烂的治疗效果,以及高频电波刀环切术结合纳米银与单纯高频电波刀在妇科疾病中的应用效果。方法:以"纳米银;纳米银凝胶;阴道炎;宫颈炎"为检索词,检索2006-01/2010-12相关文章。纳入与纳米银凝胶治疗阴道炎相关研究文献;排除重复研究或Meta分析类文章。以25篇文献为主进行分析。结果:纳米银凝胶是采用先进的纳米技术,将单质银制成粒径约25nm左右粒子,由于其量子效应、小尺寸效应和极大的比表面积特性,易于吸收,效果较好。纳米银凝胶可在阴道和宫颈部位形成层保护膜,从而杀灭致病微生物。可减少阴道排液及缩短阴道排液时间。结论:纳米银制剂具有安全、广谱、高效的抗菌、杀菌作用,易于为患者接受,但纳米银的生物安全性还有待进一步研究。

OBJECTIVE： To analyze the effects of nano-silver gel on vaginitis and cervical erosion at different levels and different types, and to compare the efficacy of LEEP combined with nano-silver and simple LEEP in treatment of gynecological diseases. METHODS： Relevant articles published in 2006-01/2010-12 were searched using ＂nano-silver; nano-silver gel; vaginitis; cervicitis＂ as keywords. Repetitive articles and Meta-analysis were excluded. Twenty-five articles were included. RESULTS： Nano-silver gel is prepared by advanced nanotechnology, about 25 nm in diameter, and characterized as quantum effect, small size effect and large surface area, easy to be absorbed. Nano-silver gel can form a protective membrane in the vaginal and cervical parts, which can kill pathogenic microorganisms, reduce vaginal discharge and shorten the time of vaginal discharge. CONCLUSION： The nano-silver preparation is safe with broad-spectrum and highly effective antibacterial and sterilization, which is easy for patients. However, the biological safety of nano-silver has yet needed further studies.