食管支架在良恶性食管狭窄中的应用(英文)

Esophageal stents for treatment of benign and malignant esophageal stenosis

背景:近年来有研究报道食管支架采用生物可降解材料和高分子材料构成,在动物实验中已取得较好的成果,但这些方法也存在较多的问题。目的:综述食管支架的类型、临床应用及其相关并发症。方法:应用计算机检索,在标题和摘要中以"食管支架,临床应用,并发症"或"esophageal stent,clinical application,complication"为检索词进行检索。选择文章内容与食管支架的类型、临床应用、并发症及在良恶性食管狭窄中的应用相关,同一领域文献则选择近期发表或发表在权威杂志文章。根据纳入标准选择28篇文献进行综述。结果与结论:食管支架置入已成为目前食管癌且无手术治疗条件患者解除食管狭窄的重要手段,随着食管支架技术的发展从最初的金属无覆膜支架到部分覆膜支架及全覆膜支架,有效的解决了相关食管疾病,但其置入后并发症如出血穿孔、胃食管反流、再狭窄等一直没有得到有效的解决。因此在选用不同支架时需全面考虑其治疗作用和并发症的利弊关系,以期极大限度的减少其并发症的出现,提高患者的生活质量。

BACKGROUND： Recent studies have demonstrated that esophageal stent is made of biodegradable materials and polymers, and satisfactory outcomes regarding its application in animal experiments have been made, but disputation exists. OBJECTIVE： To review the type, clinical application and related complications of esophageal stent. METHODS： Using ＂esophageal stent, clinical application, complications＂ in English and Chinese, manuscripts were retrieved by reading titles and abstracts. The manuscripts that are focused on the type, clinical application, and complications of esophageal stent as well as its application in malignant esophageal stenosis and the manuscripts that were recently published or in high-impact journals were selected. Finally, 28 manuscripts were included. RESULTS AND CONCLUSIONS： Esophageal stent placement has become an important mean for esophageal carcinoma in patients who had no surgical conditions to relieve esophageal stenosis. With the development in technique, from initial membrane-free metallic stent, partial membrane-covered metallic stent to whole membrane-covered metallic stent, related esophageal diseases have been effectively solved, but the subsequent complications, such as gastrorrhagia and perforation, gastroesophageal reflux, and re-stenosis, have been not completely solved. Therefore, the therapeutic effects of different stents and the advantages and disadvantages of complications should be fully considered to reduce the complications to a largest extent and finally to improve patient＇s quality of life.