复方苦参注射液对术后胃癌DFC方案辅助治疗毒副反应的影响

Clinical observation of adjuvant chemotherapy of postoperative gastric cancer by compound Matrine injection combined with DFC chemotherapy regimen

目的观察复方苦参注射液对术后胃癌DFC方案辅助治疗的毒副反应的影响。方法将手术后经病理证实分期为Ⅱ、Ⅲ期的胃癌患者作为研究对象,随机分为复方苦参注射液联合DFC方案组(研究组)20例及单纯DFC方案组(对照组)20例。结果研究组白细胞减少、消化道反应及乏力的发生率显著少于对照组(P<0.05),肝毒性也显著少于对照组(P<0.05)。结论复方苦参注射液能减少DFC方案化疗毒副作用,增加患者化疗耐受性。

Objective To observe and compare the toxicity of compound Matrine injection in combination with DCF regimen（doce taxel＋cisplatin＋fluorouracil） and DCF regimen in the adjuvant chemotherapy of patients with postoperative gastric cancer. Methods 40 patients with postoperative Ⅱ-Ⅲ stage gastric cancer diagnosed pathologically were divided into compound Matrine injection in combination with DCF regimen group（study group） 20 cases and DCF regimen group（control group） 20 cases.Each patient was given 6 cycles and the toxicity was then evaluated. Results 25 cases could be evaluated in study group and 24 cases could be evaluated in control group. The difference of incidence rates of leucopenia,gastrointestinal,hepatic function and anergy between the two groups was significant（P 0.05） . Conclusion Compound Matrine injection can reduce toxicity in study group significantly while enhancing patients’ tolerance to chemotherapy.