血浆N末端B型利钠肽原对心力衰竭患者预后的预测价值

Prognostic forecast value of plasma N-terminal pro-B-type natriuretic peptide in heart failure patients

目的:探讨N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)对心力衰竭患者预后的预测价值。方法:检测206例患者不同时间的血浆NT-proBNP浓度,分析不同病因及不同分级心力衰竭患者血浆NT-proBNP浓度的比较结果,并分析NT-proBNP与心血管事件发生的关系。结果:不同病因患者的NT-proBNP含量比较,差异无统计学意义(P>0.05);血浆NT-proBNP浓度随心力衰竭的分级增大而升高(P<0.05);随访发生心血管事件患者的左室射血分数低于未发生心血管事件者(P<0.05);NT-proBNP浓度与是否发生心血管事件明显相关(P<0.05);死亡组入院时血浆NT-proBNP浓度高于存活组,差异有统计学意义(P<0.05)。结论:血浆NT-proBNP浓度在患者发生心力衰竭时显著升高,其检测值越高,患者发生心血管事件的可能性越大,其对心力衰竭患者再次发生心血管事件的预测具有一定的价值。

Objective： To explore the prognostic forecast value of N-terminal pro-B-type natriuretic peptide （NT-proBNP） in heart failure patients. Methods： 206 patients were detected the plasma NT-proBNP concentration at different times. NT-proBNP concentrations of different etiology and classification of heart failure patients with different plasma were analyzed. The relationship between NT-proBNP and cardiovascular events happened were analyzed. Results： There was no significant difference of NT-proBNP value in patients with different causes （P〉0.05）; NT-proBNP concentration were increased with the increasing of higher classification of heart failure （P〈0.05）; in follow-up, left ventricular ejection fraction of patients with cardiovascular events were lower than those of without cardiovascular events （P〈0.05）; NT-proBNP concentrations were significantly related to cardiovascular events （P〈0.05）; plasma NT-proBNP on admission of death group was significantly higher than that of the survival group, and there was a significant difference between them （P〈0.05）. Conclusion： NT-proBNP plasma concentration in patients with heart failure are significantly higher, The higher the value of its detection, the larger likelihood of cardiovascular events in patients. There is a certain value on the recurrence of cardiovascular events in patients with heart failure prediction.