层粘连蛋白和血浆尿激酶型纤溶酶原激活物受体在子宫内膜异位症患者在位内膜中的表达及意义

Expression and significance of laminin and plasma urokinase type fibrinolytic enzyme receptors in the normal position endometriem of patients with endometriosis

目的:为给子宫内膜异位症(EMs)新的诊断与治疗方法提供一些理论依据,对不同个体的子宫内膜中是否存在层粘连蛋白(LN)及血浆尿激酶型纤溶酶原激活物受体(uPAR)表达的差异进行探讨,同时探讨这种差异可能产生的临床价值。方法:留取的子宫内膜组织标本来源于2009年10月～2011年1月在我院妇产科住院行腹腔镜或开腹手术治疗的76例盆腔EMs、非盆腔EMs及子宫腺肌症患者,分为三组,即盆腔EMs组、非盆腔EMs组、子宫腺肌症组。内膜病理诊断以子宫切除或诊刮送病检的病理结果为准。结果:对子宫内膜匀浆液中LN水平进行两两比较,经Q检验结果显示,盆腔EMs组与非盆腔EMs组、子宫腺肌症组与非盆腔EMs组、盆腔EMs组与子宫腺肌症组之间,差异均有统计学意义(均P<0.05)。结论:非盆腔EMs的子宫内膜、子宫腺肌症及盆腔EMs的在位内膜中LN水平存在差异且依次减低,在Ⅲ～Ⅳ期EMs中LN水平最低。

Objective： To give some new theoretical basis and treatment methods for different individual of EMs, not only to discuss the differences appearing in different individual endometrial in uPAR and LN, but also to discuss the differences may have clinical value. Methods： The Tissue samples were obtained from the patients treated in the Department of Gynaecology and Obstetrics in our hospital from October 2009 to January 2011 who were EMs, non-EMs and adenomyosis of uterus. They were divided into three groups, namely pelvic EMs group, non-EMs group and adenomyosis of uterus group. Pathology diagnose of endometrium took the hysterectomy or curettage as the standard of pathological test. Results： Endometrial evenly grout LN level in the binary comparison was as follows, inspection results showed that, after Q detection, pelvic EMs group and non-EMs group, adenomyosis of uterus group and non-EMs group, pelvic EMs group and adenomyosis of uterus group, there were all significant differences （all P〈0.05）. Conclusion： Non-EMs endometrial, adenomyosis of uterus, pelvic EMs in ectoplc, LN level of order varies and decreases gradually, the LN of EMs level in Ⅲ to Ⅳ period is the lowest.