结直肠癌血清CEA和CA19-9的表达与临床意义分析

Clinical analysis of the value and expression of serum CEA and CA19-9 in patients with colorectal carcinoma

目的：探讨结直肠癌患者血清中CEA、CA19—9的表达及其临床检测的意义。方法：选取我院2009年1月～2010年12月确诊的结直肠癌患者52例为结直肠癌组，选取同期40例健康体检者为健康对照组，均进行CEA、CA19—9检测，并对两指标表达均阳性的19例患者进行治疗后跟踪检测。结果：结直肠癌组CEA、CA19—9水平均显著高于健康对照组（P〈0．01）。CEA、CA19—9单项检测均有较高特异性，两指标联合检测敏感性、有效性均提高，但较CEA、CA19—9单项目检测，差异无统计学意义（P〉0．05）。两指标均阳性的19例患者治疗后CEA、CA19—9水平均较治疗前明显降低（P〈0．05），且绝大部分恢复正常。结论：CEA、CA19—9检测对结直肠癌患者早期诊断、疗效判定及复发预测均具有重要价值。

Objective： To explore the clinical value and expression of serum CEA and CA19-9 in patients with colorectal carcinoma. Methods： 52 patients who were diagnosed as colorectal carcinoma in our hospital from January 2009 to Deeember 2010 were selected as colorectal carcinoma group, and 40 cases who were healthy in physical examination of our hospital at the same time were selected as normal control group. Serum level of CEA and CA19-9 were measured in the two groups. After treatment, 19 patients with colorectal carcinoma who were measured positive in two tumor markers were measured again. Results： The levels of CEA and CA19-9 in colorectal carcinoma group were obviously higher than those in normal control group （P〈0.01）. The specificity of single tumor marker of CEA and CA19-9 were high. Sensitivity and effectiveness of the two markers united measuring were higher, but there was no difference between them （P〉0.05）. After treatment, the levels of CEA and CA19-9 in 19 patients with colorectal carcinoma who were measured positive on two tumor markers were significantly reduced （P〈0.05）, and most of who were recovered. Conclusion： The measurement of CEA and CA19-9 in serum of patients with colorectal carcinoma has important value in diagnosis, outcome and recurrence predict.