血清超敏C反应蛋白检测在评价肺结核临床疗效中的价值

The value of serum high sensitivity-C reactive protein in the evaluation of clinical efficacy in pulmonary tuberculosis

目的：探讨血清超敏C反应蛋白（hs—CRP）在评价肺结核患者治疗效果中的临床应用价值，为肺结核的临床治疗提供依据。方法：选择2008年1月～2010年10月我院收治的肺结核患者108例，分别于治疗前和治疗后检测并比较分析血沉（ESR）和hs—CRP水平。结果：在治疗后1个月对92例好转和16例病情未见好转的患者中ESR和hs-CRP检测后发现：ESR治疗前后差异无统计学意义（t=1．86，P〉0．05），而hs—CRP在好转患者中治疗后水平远远低于治疗前水平，差异有统计学意义（t=11．47，P〈0．01）。结论：hs—CRP较ESR更能反映结核病患者治疗效果。并且稳定性高，检测简单，值得临床广泛推广应用。

Objective： To investigate the value of Serum high sensitivity-C reactive protein （hs-CRP） in the evaluation of clinical efficacy in pulmonary tuberculosis, provide a theoretical basis for the clinical treatment of tuberculosis. Methods： 108 patients with tuberculosis in our hospital from January 2008 to October 2010 were detected comparative analysis ESR and hs-CRP levels before treatment and after treatment. Results： The ESR and hs-CRP levels of which 92 patients improved and 16 cases of patients with the disease not improved one month after treatment revealed： ESR before and after treatment was not statistically significant （t=1.86, P〉0.05）, but hs-CRP in the patients who improved after treatment were well below the level before treatment, the difference was statistically significant （t=11.47, P〈0.01）. Conclusion： Hs-CRP is more sensitive than ESR to reflect therapeutic effect of tuberculosis patients, and high stability, detected simply, worthy to be widely used.