宫内生长受限引起成年人代谢综合征的表观遗传机制研究进展

Prospects for epigenetic mechanisms of the adult metabolic syndrome after intrauterine growth restriction

胎儿宫内生长受限是指胎儿出生体质量低于同胎龄平均体质量的第10百分位数。宫内生长受限与成年后代谢综合征的发生密切相关，宫内环境不良引起的表观遗传改变很可能是成年后发生胰岛素抵抗的重要原因。该文从表观遗传修饰及其重点DNA的甲基化，宫内生长受限与DNA甲基化，宫内生长受限致关键启动子的表观遗传标记改变及可能的干预措施介绍宫内生长受限引起成年代谢综合征的表观遗传机制的研究进展。

Intrauterine growth restriction are those whose birth weight lie below the 10th percentile for that gestational age. Intrauterine growth restriction increases the risk of developing metabolic syndrome in later life. Epigenetic changes induced by an adverse fetal environment are strongly implicated as causes of later resisted insulin action. This review is focus on epigenetic modifications, with a focus on DNA methylation; intrauterine growth restriction and DNA methylation; epigenetic changes in key promoters induced by intrauterine growth restriction and possible interventions to describe the topic.