摘要
Connexin（Cx43）作为最重要的间隙连接蛋白，是哺乳动物心脏中最主要的连接蛋白。Cx43对心脏发育、心脏电生理活动、心肌的缺血后修复起重要作用，Cx43异常是很多心血管疾病包括先天性心脏病、缺血性心脏病、心律失常、高血压的重要病因。Cx43表达受多种因素影响，包括甲基化修饰、组蛋白修饰和非编码RNA调控等，这些调控机制的异常可能是其影响疾病发生、发展的重要因素。
As the most important gap junction protein, connexin 43 （ Cx43 ） is the most important connexiu in the mammalian heart. Recent studies suggest that it plays an important role in heart development, cardiac electrophysiological activity and cell repair after myocardial ischemia. Cx43 abnormity is an important cause of many cardiovascular diseases including congenital heart disease, ischemic heart disease, arrhythmias and hypertension. The expression of Cx43 is regulated by various factors, including methylation, histone modification and non-coding RNA regulation, etc. These abnormal regulations may be important for the development of diseases.
出处
《国际儿科学杂志》
2011年第5期470-473,共4页
International Journal of Pediatrics
基金
国家自然科学基金重点项目（30930096）
国家自然科学基金青年科学基金项目（30901624）
关键词
连接蛋白
心血管疾病
表达调控
Connexin
Cardiovascular diseases
Expression regulation
