糖耐量减退与冠状动脉病变关系的研究

The research on impaired glucose tolerance and clinical epidemiological characteristics of coronary artery disease

目的探索糖耐量减退与冠状动脉病变的关系,为预防控制冠心病提供科学依据。方法 125例冠心病患者分为正常糖耐量组(A组)、糖耐量减退组(B组)、2型糖尿病组(C组),所有病例均测定口服75 g葡萄糖2 h后血糖、空腹血糖、胰岛素、糖化血红蛋白、血脂等指标,并行冠状动脉造影,采用单因素方差分析,校正的χ2检验对上述临床资料进行分析。结果 A、B、C组空腹血糖、口服75 g葡萄糖2 h后血糖等指标的差异有统计学意义(均有P<0.05),B、C组的冠状动脉造影均显示病变,且多支血管病变的患病率明显高于A组,差异有统计学意义(均有P<0.05),而B组和C组间多支血管病变的患病率的差异无统计学意义(均有P>0.05)。结论冠心病合并糖耐量减退患者的冠状动脉病变程度较正常糖耐量者更为严重,应采取综合措施进行干预。

Objective To observe the the relation of impaired glucose tolerance and coronary artery lesions, so as to provide scientific basis for prevention and control for coronary heart disease. Methods A total of 125 eases with coronary heart disease were divided into normal glucose tolerance group, combined impaired glucose tolerance group and type 2 diabetes mellitus group, according to oral glucose tolerance test; the fasting plasma glucose, two hour postprandial blood glucose after taking 75 g oral glucose, insulin, glycosylated hemoglobin, serum lipids and so on were detected, meanwhile all cases were examined by coronary angiography. Results There were significant differences of fasting blood glucose, two hour postprandial blool glucose after taking 75 g oral glucose among GroupA, B and C. The changes of coronary arteries of patients of Group B and C were severer, more multivessel vascular lesions were found. There were no significant differences between Group B and C. Conclusions The changes of coronary arteries of patients of impaired glucose tolerance group were more severer than normal glucose tolerance group, comprehensive measures should be taken to intervene coronary heart disease.