小金缓释微丸的制备及其体外释放度考察

Preparation and Release Test in vitro of Xiaojin Sustained Release Pellets

目的:制备小金缓释微丸,并以阿魏酸为指标,考察不同包衣条件下小金缓释微丸的体外释放度。方法:采用单因素试验优选包衣工艺。结果:以乙基纤维素为包衣材料,包衣增重10%,致孔剂乳糖的用量为12%,可满足10 h缓释的要求。结论:包衣材料、包衣增重以及致孔剂的用量是影响药物释放的关键因素。

Objective：To prepare Xiaojin sustained release pellets and investigate release in vitro of Xiaojin sustained release pellets with different coating conditions by ferulic acid was determined as index.Method：Single factor test was applied to optimize the coating formulations.Result：A 10 h-sustained release curve was satisfactorily obtained by using EC as coating material and lactose 12% as porogenic agent in the optimized coating formulation with a 10% of coating weight gained.Conclusion：Coating material,coating weight gained and the amount of porogenic agent are the key factors that can significantly affect the drug release in vitro.