红景天口服液对阳虚小鼠的抗应激作用

Anti-stress Effect of Rhodiola crenulate Oral Liquid in Mice with Yang Deficient

目的:研究红景天口服液对氢化可的松致小鼠阳虚模型动物的保护作用。方法:雄性昆明种小鼠50只,按体重随机分为5组,每组10只,空白对照组、模型对照组、男宝胶囊组、红景天低、高剂量组。im氢化可的松25 mg.kg-1每天1次,连续给药5 d建立小鼠阳虚模型。造模后ig给予生理盐水(空白对照、模型对照)、男宝胶囊2.0 g.kg-1、红景天口服液低、高(2.48,24.80 g.kg-1)剂量,连续7 d,每天2次。观察动物的体重、性器官、附性器官和免疫器官质量系数的变化,测定自主活动次数、体温和低温游泳时间等指标。结果:造模动物的体重、活动次数、体温、低温游泳时间、胸腺和附性器官指数较空白对照组有明显的下降(P<0.01);ig红景天口服液后,体重、体温、胸腺和附性器官指数较模型对照组有明显的增加(P<0.01或P<0.05)。结论:红景天口服液对于im氢化可的松致阳虚小鼠动物模型可能具有抗应激作用。

Objective：To observe the protective effect of Rhodiola crenulate oral liquid（RCOL） on Yang deficiency induced by hydrocortisone in rats.Method：Fifty Kunming male mice were randomly divided in 5 groups with 10 mice each group.The mouse model of Yang deficiency was induced by intramuscular injection of hydrocortisone（25 mg·kg-1） for 5 days.On the fifth day of administration,normal saline（blank control and model control） Nan-bao capsule,RCOL（2.48,24.80 g·kg-1） were orally treated for 7 days,twice a day.The weight of mice,the coefficient of sex organs and immune organs,independent activity,the body temperature and the swimming time in cold water,were observed.Result：The weight,activity times,body temperature,the swimming time in cold water,the indexes of thymus and accessory sex organs in the model group were lower than that those in blank group（P0.01）.The weight,body temperature,the indexes of thymus and accessory sex organs in RCOL groups were higher than that in model group（P0.01 or P0.05）.Conclusion：RCOL has anti-stress effect on Yang deficient induced by hydrocortisone in mice.