葎草化学成分研究

Chemical constituents of Humulus scandens

目的研究葎草的化学成分。方法利用硅胶柱色谱、薄层色谱、Sephadex LH-20柱色谱等方法分离纯化化合物,利用核磁共振波谱鉴定化合物结构。结果从葎草干燥全草中分离并鉴定了11个化合物:(24R)-stigmast-7,22(E)-dien-3β-ol(1)、胡萝卜苷(2)、豆甾烷-3,6-二酮(3)、epidioxyergosta-6,22-dine-3β-ol(4)、豆甾醇(5)、大豆脑苷II(6)、齐墩果酸(7)、邻苯二甲酸-双-(2-乙基)-1-己酯(8)、东莨菪内酯(9)、白桦脂酸(10)、大豆脑苷I(11)。结论化合物1、3、4、6～11为首次从该属植物中分离得到。

Objective To study the chemical constituents of Humulus scandens.Methods The compounds were isolated and repeatedly purified by silica gel,TLC,and Sephadex LH-20 column chromatography,and their structures were elucidated on the basis of physicochemical constants and spectral analysis.Results Eleven compounds were obtained and elucidated as（24R）-stigmast-7,22（E）-dien-3β-ol（1）,daucesterol（2）,stigmast-3,6-dione（3）,epidioxyergosta-6,22-dine-3β-ol（4）,stigmasterol（5）,soya-erebroside II（6）,oleanolic acid（7）,bis-（2-ethylhexyl） phthalate（8）,scopoletin（9）,betulimicaciol（10）,and soya-erebroside I（11）.Conclusion The compounds 1,3,4 and 6―11 are isolated from the plants of Humulus Linn.for the first time.