降钙素原、白细胞计数以及C反应蛋白在新生儿感染性疾病中的应用

Precalcitonin,white blood cells and C reative protein in newborn with infectious diseases

目的:通过检测患有新生儿感染性疾病的患儿血清中的降钙素原(PCT)、C反应蛋白(CRP)和血液中的白细胞计数(WBC)水平,探讨其对新生儿感染性疾病中辅助诊断作用。方法:选用临床确诊为患有感染性疾病的新生患儿42例,健康新生儿30例,检测其血清中的PCT、CRP以及血液中的WBC,用统计软件Spss 17.0进行数据分析。结果:42例新生患儿中PCT阳性率(PCT≥0.5 ng/mL为阳性)为90.5%,WBC阳性率(WBC>20×109/L为阳性)为28.5%,CRP阳性率(CRP>8 mg/L为阳性)为44.7%,三者在新生儿感染性疾病中均升高,但是PCT阳性率明显高于CRP和WBC,存在显著差异性(P<0.01)。结论:PCT、WBC和CRP对新生儿感染性疾病的诊断,鉴别诊断和指导临床早期用药有一定的价值,而且相比于WBC和CRP,PCT是一个能够更早,更灵敏地反映新生儿感染性疾病的指标。

Aim： To explore the clinical applications of the PCT,CRP and WBC in neonatal infectious diseases.Methods： The serum levels of PCT and CRP,as well as the plasma WBC of 42 newborn children who suffered from infection disease and 30 healthy newborn were detected and spss 17.0 was used to analysis.Results： Three levels of marker of infectious diseases were higher,but the positive rate of PCT is higher than that of WBC and CRP,there are significant differences（P0.01）.Conclusion：Having a clinical value of PCT,WBC and CRP for infectious disease diagnosis,differential diagnosis and early use of drug,PCT is an earlier,more sensitive marker for the newborn children suffering from infection diseases.compactted with WBC or CRP.