65例精神病患者红细胞锂评价研究

Evaluation studies on erythrocyte lithium in 65 psychotic patients

对锂盐治疗获显效的55例和效差(无效和好转)的10例情感性和分裂情感性精神病作了红细胞锂(ELL)和血清锂(SLL)的测定和分析。服锂剂量:从0.3-0.6g/d开始,10d左右加至1.2-2.1g/d。结果。效差组ELL低于显效组并有显著差异。提示对锂盐效差与ELL浓度低有关。

Lithium level of erythrocyte(ELL)and serum(SLL)were measured in 65 patients with affective disorder and schizoaffective psychosis during the treatment. Beginning with dosage of 0.3-0.6 g/d, increasing to 1.2-2.1 g/d within ten days. Fifty-five patients were markedly improved and ten non-responded. The result showed that ELL of the non-responders was significantly lower than that of the responders. The distributing values of the ELL among all were much more variable than those of the SLL. It is suggested that the ELL in the patients with poor therapeutic effect tends to be in low level.