α-细辛脑治疗癫痫32例

α-Asarone in the treatment of epilepsy in 32 patients

本文报道α-细辛脑治疗癫痫大发作及精神运动性发作共32例,剂量90-270mg/d,有效率为59％,其中15例单独接受α-细辛脑(另17例接受α-细辛脑加其它抗癫痫药)有效率为59％;另一组15例单独用苯妥因治疗具同样发作类型的癫痫病人进行对照观察,有效率为53％。后者与上述2组比较均无显著差异,而且不良反应小,说明α-细辛脑控制癫痫的疗效可与苯妥因相媲美,是一新型抗癫痫药。

Thirty-two patients proved epilepsy had their grand mal or psycho-motor seizure attacks controlled with a-asarone, the daily dosage was 90mg to 270 mg, and the efficacy rate was 59%. A control group consisting of 15 cases of epileptic patients were treated with phenytoin, and the efficacy rate was 53%. There was no significant difference between these two groups. It is suggested that a-asarone have the same efficacy as phenytoin in controlling seizures and have the advantage of fewer adverse effects and larger safety range of dosage. So a-asarone may regard as a new anticonyulsant drug.