不同血液净化方式治疗不安腿综合征的疗效观察

Clinical observation of curative effects of different blood purification methods on restless legs syndrome

目的观察血液灌流(HP)串联血液透析(HD)治疗不安腿综合征的临床疗效,探讨不同血液净化方式治疗不安腿综合征的优越性。方法将26例有不安腿综合征的长期维持血液透析的病人随机分为治疗组(13例)和对照组(13例),对照组常规行血液透析治疗,治疗组行血液灌流串联血液透析(HP+HD)治疗(1次/w),连续2个月。观察2组治疗2个月前后临床表现及血清甲状旁腺激素(PTH)浓度变化。结果治疗组总有效率84.62%,治疗后PTH浓度明显下降(P<0.01)。对照组治疗后临床症状及PTH均无明显变化,总有效率23.07%,低于治疗组的总有效率(P<0.01)。结论 HP+HD治疗不安腿综合征明显优于单独使用HD治疗。

Objective To observe the clinical effects of hemoperfusion（HP） combined with hemodialysis（HD） on restless leg syndrome,and discuss the advantages of different blood purification methods for this syndrome.Methods 26 patients with restless leg syndrome and receiving long-term maintenance-hemodialysis were randomly divided into treatment group（13 cases） and control group（13 cases）.The control group only received HD,while the treatment group received HP combined with HD once a week for two successive months.Changes of clinical manifestation and concentration of serum parathyroid hormone（PTH） of the two groups were observed before and after the treatment.Results The total effective rate of the treatment group was 84.62%.After the treatment,the concentration of PTH decreased significantly（P〈0.01）.The total effective rate of the control group was 23.07%,which was lower than that of the treatment group（P〈0.01）.There were no obvious changes of the clinical manifestation and PTH in the control group after the treatment.Conclusion The curative effect of HP combined with HD for restless leg syndrome is obviously better than that of HD alone.