摘要
目的探讨2型糖尿病合并下肢动脉粥样硬化的危险因素。方法回顾性分析我院收治的234例2型糖尿病患者,按照彩色超声检查,将108例2型糖尿病合并下肢动脉粥样硬化患者作为病例组,126例未发生下肢动脉粥样硬化的患者作为对照组。比较病例组与对照组患者的糖尿病病程、年龄、收缩压、舒张压、体质指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、空腹胰岛素(FINS)、血脂[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、胰岛素抵抗指数(HOMA-IR)、尿微量清蛋白(UMA)等因素,并对因素做多元线性回归分析。结果病例组与对照组的糖尿病病程、收缩压、FBG、2 hPBG、TG、HDL-C、HbA1c、LDL-C、FINS、UMA比较,差异有统计学意义(P<0.05)。回归分析显示,FBG、LDL-C、HbA1c、UMA是糖尿病下肢动脉粥样硬化的独立危险因素。结论防治2型糖尿病合并下肢动脉粥样硬化应同时进行多因素全面控制,尤其应注意血糖、血压、脂代谢和UMA的控制。
Objective To explore the risk factors for type 2 diabetes with complicated lower extremity arterial athero- sclerosis. Methods Retrospective analysis was carried out in 234 hospitalized patients with type 2 diabetes, who were divided in- to two groups according to color Doppler ultrasound examination: the ease group ( 108 patients with lower extremity arterial ather- osclerosis) and the control group ( 126 patients without lower extremity arterial atherosclerosis) . Factors including duration of di- abetes, age, SBP, DBP, BMI, HbAlc, FBG, 2 hPBG, FINS, TG, TC, LDL-C, HDL-C, HOMA-IRand UMA were compared between the two groups and multivariate linear regression analysis was performed on these factors. Results Diabetes du- ration, SBP, FBG, 2 hPBG, TG, HDL- C, HbA1c, LDL- C, Hb1c, and UMA showed statistically significant differences between the case group and the control group (P 〈 0. 05 ) . Regression analysis showed that FBG, LDL - C, FINS, and UMA were among the independent risk factors of diabetic lower limb atherosclerosis. Conclusion Prevention of type 2 diabetes with complicated lower extremity atherosclerosis calls for comprehensive control of multiple factors, with particular attention to blood sugar, blood pressure, lipid metabolism and UMA paid.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第26期2953-2955,共3页
Chinese General Practice
关键词
糖尿病
2型
动脉粥样硬化
危险因素
Diabetes mellitus, type 2
Atherosclerosis
Risk factors