水红花子对免疫肝纤维化大鼠肝功能及血清肝纤维化标志物的影响

Effect of Fructus Polygoni Orientalis on the Liver Function and Serum Liver Fibrosis Markers of Immune Liver Fibrosis Rats

目的观察水红花子对免疫肝纤维化大鼠模型血清肝纤维化标志物的影响。方法 40只wistar大鼠随机分为正常对照组、模型对照组、秋水仙碱组、水红花子组。除正常对照组外,其余各组均给予腹腔注射无菌猪血清,剂量为0.3mL/100g,每周2次,连续12周。模型对照组、正常对照组每日灌服蒸馏水1mL/100g;其余各组灌服相应药物。采用放射免疫的方法观察肝纤维化大鼠血清肝纤维化指标(HA、LN、Ⅳ-C、PCⅢ)的变化。结果与模型对照组比较,各治疗组血清学标志物均有不同程度改善,其中秋水仙碱组PCⅢ、HA、LN显著降低;水红花子组LN、PCⅢ、HA、Ⅳ-C显著降低。结论水红花子可有效降低肝纤维化血清学指标,其作用优于秋水仙碱。

Objective：To explore the effect of fructus polygoni orientalis on the serum liver fibrosis markers of immune liver fibrosis rats.Methods：40 wistar rats were divided randomly into the normal group,the model group,the colchicinum group and the fructus polygoni orientalis group.Excluding the control group,3 groups were injected 0.3mL/100g swine serum to set up liver fibrosis.The model group and the normal groups were given NS frombaseline lmL/100g.Another groups were given the same volume/weight medicine respectively.Indices of serum liver fibrosis were observed by the radioimmunoassay method.Results：Compared with the model group,serum indices in the treatment group and the control group were improved.In the colchicinum group,the PCⅢ,HA and LN were decreased obviously.In the fructus polygoni orientalis group,the LN,PCⅢ,HA and Ⅳ-C were reduced remarkably.Conclusion：Fructus polygoni orientalis can significantly reduced the elevate levels of serum markers of liver fibrosis.Its effect is superior to that of the colchicinum.