洛哌丁胺治疗非感染性腹泻81例

Loperamide controls noninfectious diarrhea in 81 patients

用国产洛哌丁胺治疗各种病因引起的非感染性急慢性腹泻共81例,以复方地芬诺酯治疗非感染性急慢性腹泻62例作对照。急性腹泻病例先口服洛哌丁胺4mg,以后每次2mg,每天总量不得超过16mg。慢性腹泻病例,每日给服洛哌丁胺2-6mg。连续给药10d无效者停药。儿童剂量根据年龄或体重调整。结果:在急性病例中洛哌丁胺与复方地芬诺酯控制腹泻的效果相似;在慢性腹泻病例中,前者的疗效明显优于后者。洛哌丁胺治疗后血、尿常规,肝、肾功能与心电图观察均无异常。

In order to confirm the efficacy of loperamide for controlling the noniafectious diarrhea, with diphenoxylate Co.(contain 2.5 mg diphenoxylate and 0.025 mg atropine sulfate)as a control,143 patients of noninfectious diarrhea , diagnosed by laboratory stool examinations were studied-81 patients received loperamide while 62 patients diphenoxylate Co.During the acute attack, lopera-mide 4 mg was given per os as an initial dose, followed by 2 mg for 3d. The daily dose was limited to 16 mg as a maximum.For chronic patients, loperamide 2-6 mg /d were given.Dosages for children were adjusted according to their body weight or age. In conclusion, loperamide has the same efficacy as diphenoxylate Co. to control the acute noninfectious diarrhea and the former is even better than the latter for those chro-nic patients to have symptomatic release.In addition, lopera-mide rarely develops adverse reactions.