某院2007～2010年鲍曼不动杆菌的临床分布及耐药性分析

Clinical distribution and antimicrobial resistance analysis of Acinetobacter baumannii isolates in a hospital during 2007-2010

目的分析鲍曼不动杆菌的临床分布及耐药情况，为临床合理使用抗菌药物提供参考。方法采用回顾性分析方法对2007-2010年临床分离鲍曼不动杆菌的分布情况和耐药性进行分析。结果512株鲍曼不动杆菌的临床标本来源以痰和伤口分泌物为主，分别占78．5％和11．9％。2007～2009年鲍曼不动杆菌对美洛培南、亚胺培南耐药率均在8．0％以下，而2010年耐药率上升至26．55％。结论福州市第二医院鲍曼不动杆菌的耐药率低于其他综合医院。该菌连续4年抗菌药耐药性监测显示了其多重耐药性，且其感染和耐药性在临床呈逐年上升趋势，特别是2009年以来上升尤为突出，须引起，临床关注。

Objective To analyze the clinical distribution and drug resistance characteristics in isolates of Acinetobacter baumannii （AB）,and to provide the valuable reference data for rational selection of antimicrobial agents. Methods The infection distribution and antimicrobial resistance test of Ab isolated from our hospital during 2007-2010 were analyzed retrospectively. Results Among 512 isolates,78.5% were from sputum and 11.9% were from secretion. The drug resistance rates to imipenem and meropenem were less than 8.0% from 2007 to 2009,but risen to 26.55% in 2010. Conclusion Antimicrobial resistance of Ab isolates in our hospital were less than that in other general hospitals. But it shows multi-drug resistance in continuous four years. The infection and resistance rate appear the increasing trend year by year, especially in 2010 ,which needs to arouse clinical concern.