尼可地尔对急性心肌梗塞患者血流动力学的影响

Hemodynamic effects of nicorandil in patients with acute myocardial infarction

11例急性心肌梗塞患者(男10女1,年龄62±SD9 yr)于发病3d内入院,用尼可地尔15-20mgpo,监测服药前、后的血流动力学变化,结果显示服用尼可地尔后心率减慢,血压、右心房压、肺楔嵌压、体循环及全肺阻力下降,心脏指数增加(P<0.05);药物作用于服药后1-2h最明显,4h仍有作用。示该药可改善患者的血流动力学指数。

Eleven patients(10 M & 1 F, aged 62+9 yr) with acute myocardial in-farction(AMl) were admitted within 3 d following the attack.Swan-Ganz catheter was inserted to record the hemodynamic parameters accordingly. Following nicor-andil 15-20 mg po, heart rate (HR) was decreased, mean arterial blood pressure (mBP), right atrial pressure(RAP), systemic and pulmonary vascular resistance were all reduced and approximated to the normal, and the cardiac index(CI) was definitely improved.The action was quite distinct within 1-2 h after medication and could be maintained even 4 h in some patients, Suggestions were made that hemody-namics in AMI can be improved by nicorandil.