首发抑郁症患者治疗前后脑电图变化的研究

The study of electroencephalogram in first-episode depression before and after therapy

目的:研究首次抑郁症发作患者治疗前后脑电图的改变。方法:对38例抑郁症首次发病患者于治疗前和治疗12周采用汉密顿抑郁量表(HAMD)17项评定症状严重程度,并进行脑电图测试。结果:治疗第12周末,HAMD总分下降,减分率达(71.3±20.8)%3,2例(84.2%)的患者达到临床痊愈标准。治疗前脑电图异常率44.7%,治疗后异常率仅为10.5%,两组比较有显著性差异(P<0.01)。治疗前脑电图以轻度异常为主,表现为基本电活动变慢,慢活动增多。结论:脑电图改变可能是抑郁症患者的早期改变,并可作为治疗监测及疗效评定的重要参考依据。

Objective：To study the electroencephalogram（EEG） in first episode depression before and after treatment. Methods ：Sixty- three patients with first episode depression were evaluated by HAMD 17, and electroencephalogram tests were recorded at the baseline and week 12. Results： The reduction on the HAMD score at weeks 12 was （71.3 ± 20.8 ）% , and 32 cases （84.2%） were clinical remission. The abnormality rate of electroencephalogram was 44.7% before treatment and 18.4% after treatment. The difference was significant between before and after treatment（ P 〈 0. 01 ）. The electroencephalogram change before treatment was mainly paranormal. It showed basic electric activity becoming slow, slow activities increased. Conclusions： The results suggest there is abnormal electroencephalogram in the early stage of depression, and it might provide important evidences to monitor the effect of medicine.